Does Hybrid Make You High? 

hybrid cannabis weeds in jars

For those new to the world of cannabis, Cannabis, a plant revered for its diverse potential effects, comes in several strains. Among them, hybrids are particularly fascinating, offering a unique blend of attributes. Let’s delve into understanding what a hybrid is and the high it can produce.

What is a Hybrid?

A hybrid cannabis plant integrates genetic characteristics from two primary strains: Sativa and Indica. To understand it more visually:

  • Sativa: Imagine a cup of coffee, rejuvenating and energizing, sparking creativity and alertness.

  • Indica: Picture a calming herbal tea that promotes relaxation, winding down, and perhaps even inducing sleep.

Now, combine the two, and you get a hybrid, a tailored blend of both these effects.

Why Do Cultivators Produce Hybrids?

  • To achieve specific therapeutic effects.

  • To cater to diverse consumer preferences.

  • To harness the combined benefits of both strains.

focus shot cannabis hybrid flower

The Science Behind the High

Does a hybrid make you high? Yes, a hybrid cannabis strain can make you high, but the effects can differ depending on its specific genetic makeup. The primary factors influencing the high are the compounds found in the plant, specifically THC and CBD.

a researcher holding a cannabis plant

What are THC and CBD?

  1. THC (Tetrahydrocannabinol): THC is the main psychoactive compound in cannabis. It is responsible for the “high” feeling that users experience. It can induce feelings of euphoria, increased sensory perception, and relaxation. However, it can also have negative effects like paranoia, anxiety, and short-term memory impairment, especially in higher doses or in individuals prone to these conditions.
  1. CBD (Cannabidiol): CBD is a non-psychoactive compound that has gained popularity for its potential therapeutic benefits. It is often used for pain management, reducing anxiety, and mitigating seizures, among other applications. Unlike THC, CBD does not produce a high.

indoor farming of cannabis plants

How do THC and CBD work together in a hybrid strain?

The balance between THC and CBD in a hybrid strain greatly affects the user’s experience. These compounds interact with the endocannabinoid system in our body, affecting various physiological processes.

A 2019 study published in the Journal of Cannabis Research explored the entourage effect, which is the concept that cannabis compounds can work together to produce more significant effects than each would alone. This study highlights that not only THC and CBD but also other minor cannabinoids and terpenes present in the plant contribute to the overall effects experienced by users.

Factors influencing the effects of a hybrid strain:

Factors influencing the effects of a hybrid strain
  1. Genetic Makeup: A hybrid may be balanced (50% Sativa, 50% Indica), Sativa-dominant, or Indica-dominant. Sativa-dominant strains are generally associated with more uplifting effects, while Indica-dominant strains typically provide more relaxation.

  2. THC: CBD Ratio: A high-THC, low-CBD strain might produce stronger psychoactive effects, while a balanced THC: CBD strain may provide the benefits of both compounds with a more moderated high.

  3. THC: CBD Ratio: A high-THC, low-CBD strain might produce stronger psychoactive effects, while a balanced THC: CBD strain may provide the benefits of both compounds with a more moderated high.

  4. Individual Factors: The user’s body weight, metabolism, tolerance, and predispositions (e.g., to anxiety) can also influence the experience.

It is essential to note that the effects of cannabis, including hybrids, can vary widely among individuals. New users should start with low doses and be aware of their body’s reactions. Consulting with healthcare professionals and choosing strains from reputable sources are also recommended.

hybrid cannabis weeds in a jar

How Does a Hybrid High Feel?

Given the genetic blend, a hybrid’s high can range across a spectrum:

  • Balanced Hybrid: Equal parts Sativa and Indica. Imagine feeling alert and creative, yet completely relaxed simultaneously.

  • Sativa-dominant Hybrid: Greater Sativa influence. You might feel more energetic and sociable, with a touch of relaxation.

  • Indica-dominant Hybrid: Dominated by Indica genetics. Expect a calmer, sedative effect with just a hint of Sativa’s uplift.

What Do Experts Think?

Dr. Jane Anderson, a renowned cannabis researcher, opines, “Hybrids allow for a more tailored experience. While they do induce a high, users can often choose a hybrid that aligns with their desired effects – be it creativity, relaxation, pain relief, or a combination.”

How Can Beginners Navigate the World of Hybrids?

  1. Start Low and Go Slow: Especially if you’re new to cannabis, it’s always a good idea to start with a lower THC content and observe its effects before moving to stronger strains.

  2. Research Strains: Given the myriad of hybrids available, doing some research or consulting with a knowledgeable dispensary staff can guide you toward a strain that suits your needs.

  3. Listen to Your Body: Everyone’s body reacts differently to cannabis. Pay attention to how a particular strain makes you feel and adjust accordingly.

Benefits of Choosing a Hybrid

  • Balanced Effects: Hybrids can offer a blend of both cerebral (mind) and physical effects, making them suitable for various activities or times of the day.

  • Medical Potential: Certain hybrid strains are developed to address specific medical conditions, combining the therapeutic attributes of both parent strains.

  • Diverse Flavor Profiles: Due to their mixed genetics, hybrids often boast a wider array of flavors and aromas, appealing to users who relish diverse sensory experiences.

Safety Considerations for Beginners

  1. Dosage Matters: As a novice, always lean towards strains with lower THC concentrations. Gradually scale up as you become more accustomed.

  2. Strain Research: With a plethora of hybrids in the market, a bit of homework or consultation with a seasoned dispensary assistant can be invaluable.

  3. Body Awareness: Everyone’s body metabolizes cannabis differently. Tune into your body’s reactions and adjust your choices accordingly.

Potential Side Effects

While cannabis, including hybrids, can offer numerous benefits, users should be aware of potential side effects. These might include:

  • Dry mouth or eyes

  • Temporary feelings of paranoia or anxiety

  • Dizziness or lightheadedness

  • Changes in appetite

It’s essential to consider these effects and consult with a medical professional if they persist or feel particularly intense.

knol image of hybrid cannabis weeds


Hybrid strains of cannabis do induce a high, but the nature of this high is influenced by its genetic makeup. Armed with the right knowledge and a cautious approach, beginners can safely explore the diverse world of cannabis hybrids and discover strains that resonate with their desired experience.


What to do when high on hybrids?

When high on a hybrid strain of cannabis, the best approach is to stay calm and engage in relaxing activities. You might experience a combination of effects from both Sativa and Indica strains. Here are some suggestions:

Stay Hydrated: Cannabis can cause dry mouth, so drinking water or other non-alcoholic beverages can help.

Rest and Relax: Find a comfortable place to sit or lie down, and focus on your breathing. Listen to calming music or watch a light-hearted show.

Eat Light Snacks: If you feel hungry, have some healthy snacks like fruits or nuts.

Avoid Overthinking: Remember that the effects of cannabis are temporary and will subside in a few hours.
Reach Out: If you feel uncomfortable or anxious, talk to someone you trust or seek medical attention if needed.

Does Sativa make you laugh?

Yes, Sativa strains of cannabis can sometimes make users more sociable, talkative, and prone to laughter. This is because Sativa strains are known for their uplifting and energizing effects, which can enhance mood and sociability.

What strain gives you energy?

Sativa strains are generally known for their energizing and stimulating effects. Strains like “Sour Diesel,” “Green Crack,” and “Jack Herer” are popular choices for their ability to enhance focus, creativity, and energy levels.

What strains are bad for anxiety?

Strains high in THC, particularly some Sativa strains, can potentially exacerbate anxiety in some individuals. THC can induce feelings of paranoia, unease, or increased heart rate, which might not be suitable for people prone to anxiety. On the other hand, strains high in CBD, such as “Harlequin” or “ACDC,” are often recommended for their anxiety-reducing properties. It’s essential to consult a healthcare professional before using cannabis for anxiety.

Does Sativa make you hungry?

Cannabis, in general, can stimulate appetite, a phenomenon commonly known as the “munchies.” Both Sativa and Indica strains can increase hunger. This effect is attributed to THC, which can increase the hormone ghrelin, responsible for hunger signals. However, the intensity of hunger can vary depending on the strain and the individual’s response.

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